Featured publications
FLT3ITD drives context-specific changes in cell identity and variable interferon dependence during AML initiation
March 23, 2023
Li Y, Yang W, Patel RM, Casey EB, Denby E, Mendoza-Castrejon J, Rodriguez-Lopez P, Magee JA. FLT3ITD drives context-specific changes in cell identity and variable interferon dependence during AML initiation. Blood. 2023 Mar 23;141(12):1442-1456. doi: 10.1182/blood.2022016889. PMID: 36395068; PMCID: PMC10082380.
Layered immunity and layered leukemogenicity: Developmentally restricted mechanisms of pediatric leukemia initiation
May 1, 2023
Mendoza-Castrejon J, Magee JA. Layered immunity and layered leukemogenicity: Developmentally restricted mechanisms of pediatric leukemia initiation. Immunol Rev. 2023 May;315(1):197-215. doi: 10.1111/imr.13180. Epub 2023 Jan 2. PMID: 36588481; PMCID: PMC10301262.
Kmt2c mutations enhance HSC self-renewal capacity and convey a selective advantage after chemotherapy
February 16, 2021
Chen R, Okeyo-Owuor T, Patel RM, Casey EB, Cluster AS, Yang W, Magee JA. Kmt2c mutations enhance HSC self-renewal capacity and convey a selective advantage after chemotherapy. Cell Rep. 2021 Feb 16;34(7):108751. doi: 10.1016/j.celrep.2021.108751. PMID: 33596429; PMCID: PMC7951951.
Single-Cell Analysis of Neonatal HSC Ontogeny Reveals Gradual and Uncoordinated Transcriptional Reprogramming that Begins before Birth
August 20, 2020
Li Y, Kong W, Yang W, Patel RM, Casey EB, Okeyo-Owuor T, White JM, Porter SN, Morris SA, Magee JA. Single-Cell Analysis of Neonatal HSC Ontogeny Reveals Gradual and Uncoordinated Transcriptional Reprogramming that Begins before Birth. Cell Stem Cell. 2020 Nov 5;27(5):732-747.e7. doi: 10.1016/j.stem.2020.08.001. Epub 2020 Aug 20. PMID: 32822583; PMCID: PMC7655695.
The efficiency of murine MLL-ENL-driven leukemia initiation changes with age and peaks during neonatal development
August 13, 2019
Okeyo-Owuor T, Li Y, Patel RM, Yang W, Casey EB, Cluster AS, Porter SN, Bryder D, Magee JA. The efficiency of murine MLL-ENL-driven leukemia initiation changes with age and peaks during neonatal development. Blood Adv. 2019 Aug 13;3(15):2388-2399. doi: 10.1182/bloodadvances.2019000554. PMID: 31405949; PMCID: PMC6693010.
Recent publications
- LIN28B promotes differentiation of fully transformed AML cells but is dispensable for fetal leukemia suppressionLi, Y., Mendoza-Castrejon, J., Patel, R. M., Casey, E. B., Denby, E., Bryder, D. & Magee, J. A., 2024, (Accepted/In press) In: Leukemia.Research output: Contribution to journal › Letter › peer-review
- Basal type I interferon signaling has only modest effects on neonatal and juvenile hematopoiesisLi, Y., Yang, W., Wang, H. C., Patel, R. M., Casey, E. B., Denby, E. & Magee, J. A., Jun 13 2023, In: Blood Advances. 7, 11, p. 2609-2621 13 p.Research output: Contribution to journal › Article › peer-review
- Layered immunity and layered leukemogenicity: Developmentally restricted mechanisms of pediatric leukemia initiationMendoza-Castrejon, J. & Magee, J. A., May 2023, In: Immunological Reviews. 315, 1, p. 197-215 19 p.Research output: Contribution to journal › Review article › peer-review
- FLT3ITD drives context-specific changes in cell identity and variable interferon dependence during AML initiationLi, Y., Yang, W., Patel, R. M., Casey, E. B., Denby, E., Mendoza-Castrejon, J., Rodriguez-Lopez, P. & Magee, J. A., Mar 23 2023, In: Blood. 141, 12, p. 1442-1456 15 p.Research output: Contribution to journal › Article › peer-review
- A fetal tumor suppressor axis abrogates MLL-fusion-driven acute myeloid leukemiaEldeeb, M., Yuan, O., Guzzi, N., Thi Ngoc, P. C., Konturek-Ciesla, A., Kristiansen, T. A., Muthukumar, S., Magee, J., Bellodi, C., Yuan, J. & Bryder, D., Feb 28 2023, In: Cell Reports. 42, 2, 112099.Research output: Contribution to journal › Article › peer-review