Featured publications
Kmt2c restricts G-CSF-driven HSC mobilization and granulocyte production in a methyltransferase-independent manner
August 27, 2024
Wang HC, Chen R, Yang W, Li Y, Muthukumar R, Patel RM, Casey EB, Denby E, Magee JA. Kmt2c restricts G-CSF-driven HSC mobilization and granulocyte production in a methyltransferase-independent manner. Cell Rep. 2024 Aug 27;43(8):114542. doi: 10.1016/j.celrep.2024.114542. Epub 2024 Jul 23. PMID: 39046877.
FLT3ITD drives context-specific changes in cell identity and variable interferon dependence during AML initiation
March 23, 2023
Li Y, Yang W, Patel RM, Casey EB, Denby E, Mendoza-Castrejon J, Rodriguez-Lopez P, Magee JA. FLT3ITD drives context-specific changes in cell identity and variable interferon dependence during AML initiation. Blood. 2023 Mar 23;141(12):1442-1456. doi: 10.1182/blood.2022016889. PMID: 36395068; PMCID: PMC10082380.
Layered immunity and layered leukemogenicity: Developmentally restricted mechanisms of pediatric leukemia initiation
May 1, 2023
Mendoza-Castrejon J, Magee JA. Layered immunity and layered leukemogenicity: Developmentally restricted mechanisms of pediatric leukemia initiation. Immunol Rev. 2023 May;315(1):197-215. doi: 10.1111/imr.13180. Epub 2023 Jan 2. PMID: 36588481; PMCID: PMC10301262.
Kmt2c mutations enhance HSC self-renewal capacity and convey a selective advantage after chemotherapy
February 16, 2021
Chen R, Okeyo-Owuor T, Patel RM, Casey EB, Cluster AS, Yang W, Magee JA. Kmt2c mutations enhance HSC self-renewal capacity and convey a selective advantage after chemotherapy. Cell Rep. 2021 Feb 16;34(7):108751. doi: 10.1016/j.celrep.2021.108751. PMID: 33596429; PMCID: PMC7951951.
Single-Cell Analysis of Neonatal HSC Ontogeny Reveals Gradual and Uncoordinated Transcriptional Reprogramming that Begins before Birth
August 20, 2020
Li Y, Kong W, Yang W, Patel RM, Casey EB, Okeyo-Owuor T, White JM, Porter SN, Morris SA, Magee JA. Single-Cell Analysis of Neonatal HSC Ontogeny Reveals Gradual and Uncoordinated Transcriptional Reprogramming that Begins before Birth. Cell Stem Cell. 2020 Nov 5;27(5):732-747.e7. doi: 10.1016/j.stem.2020.08.001. Epub 2020 Aug 20. PMID: 32822583; PMCID: PMC7655695.
Recent publications
- Kmt2c restricts G-CSF-driven HSC mobilization and granulocyte production in a methyltransferase-independent mannerWang, H. C., Chen, R., Yang, W., Li, Y., Muthukumar, R., Patel, R. M., Casey, E. B., Denby, E. & Magee, J. A., Aug 27 2024, In: Cell Reports. 43, 8, 114542.Research output: Contribution to journal › Article › peer-review
- Disruption of polyunsaturated fatty acid biosynthesis drives STING-dependent acute myeloid leukemia cell maturation and deathKanefsky, J., Basse, M., Sokei, J., di Martino, O., Valin, L., Jaspers, Y., Martinez, E., Huhn, J., Di Marcantonio, D., Magee, J. A., Goldman, A. R., Tang, H. Y., Ferraro, F., Kemp, S., Wiest, D. L. & Sykes, S. M., May 2024, In: Journal of Biological Chemistry. 300, 5, 107214.Research output: Contribution to journal › Article › peer-review
- LIN28B promotes differentiation of fully transformed AML cells but is dispensable for fetal leukemia suppressionLi, Y., Mendoza-Castrejon, J., Patel, R. M., Casey, E. B., Denby, E., Bryder, D. & Magee, J. A., Mar 2024, In: Leukemia. 38, 3, p. 648-651 4 p.Research output: Contribution to journal › Letter › peer-review
- Basal type I interferon signaling has only modest effects on neonatal and juvenile hematopoiesisLi, Y., Yang, W., Wang, H. C., Patel, R. M., Casey, E. B., Denby, E. & Magee, J. A., Jun 13 2023, In: Blood Advances. 7, 11, p. 2609-2621 13 p.Research output: Contribution to journal › Article › peer-review
- Layered immunity and layered leukemogenicity: Developmentally restricted mechanisms of pediatric leukemia initiationMendoza-Castrejon, J. & Magee, J. A., May 2023, In: Immunological Reviews. 315, 1, p. 197-215 19 p.Research output: Contribution to journal › Review article › peer-review
- FLT3ITD drives context-specific changes in cell identity and variable interferon dependence during AML initiationLi, Y., Yang, W., Patel, R. M., Casey, E. B., Denby, E., Mendoza-Castrejon, J., Rodriguez-Lopez, P. & Magee, J. A., Mar 23 2023, In: Blood. 141, 12, p. 1442-1456 15 p.Research output: Contribution to journal › Article › peer-review
- A fetal tumor suppressor axis abrogates MLL-fusion-driven acute myeloid leukemiaEldeeb, M., Yuan, O., Guzzi, N., Thi Ngoc, P. C., Konturek-Ciesla, A., Kristiansen, T. A., Muthukumar, S., Magee, J., Bellodi, C., Yuan, J. & Bryder, D., Feb 28 2023, In: Cell Reports. 42, 2, 112099.Research output: Contribution to journal › Article › peer-review
- Integration of Genomic Sequencing Drives Therapeutic Targeting of PDGFRA in T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic LymphomaPaolino, J., Dimitrov, B., Winger, B. A., Sandoval-Perez, A., Rangarajan, A. V., Ocasio-Martinez, N., Tsai, H. K., Li, Y., Robichaud, A. L., Khalid, D., Hatton, C., Gillani, R., Polonen, P., Dilig, A., Gotti, G., Kavanagh, J., Adhav, A. A., Gow, S., Tsai, J. & Li, Y. D. & 20 others, Ebert, B. L., Van Allen, E. M., Bledsoe, J., Kim, A. S., Tasian, S. K., Cooper, S. L., Cooper, T. M., Hijiya, N., Sulis, M. L., Shukla, N. N., Magee, J. A., Mullighan, C. G., Burke, […]
- Single-cell RNA transcriptome analysis of CNS immune cells reveals CXCL16/CXCR6 as maintenance factors for tissue-resident T cells that drive synapse eliminationRosen, S. F., Soung, A. L., Yang, W., Ai, S., Kanmogne, M., Davé, V. A., Artyomov, M., Magee, J. A. & Klein, R. S., Dec 2022, In: Genome medicine. 14, 1, 108.Research output: Contribution to journal › Article › peer-review
- Macrophage NOX2 NADPH oxidase maintains alveolar homeostasis in miceBhattacharya, S., Idol, R. A., Yang, W., Rojas Márquez, J. D., Li, Y., Huang, G., Beatty, W. L., Atkinson, J. J., Brumell, J. H., Bagaitkar, J., Magee, J. A. & Dinauer, M. C., May 12 2022, In: Blood. 139, 19, p. 2855-2870 16 p.Research output: Contribution to journal › Article › peer-review